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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
11.21
Human Site:
T137
Identified Species:
18.97
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
T137
K
K
E
Q
M
P
L
T
P
P
R
F
D
H
D
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
T137
K
K
E
Q
M
P
L
T
P
P
R
F
D
H
D
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
T137
K
K
E
Q
M
P
L
T
P
P
R
F
D
H
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
C139
D
S
D
E
G
D
Q
C
S
R
L
L
E
L
V
Rat
Rattus norvegicus
O54735
833
94538
L137
I
F
L
H
I
H
G
L
I
S
A
D
R
Y
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
S139
P
D
A
G
D
Q
C
S
R
L
L
E
L
V
K
Chicken
Gallus gallus
P52731
862
99990
P130
F
E
D
N
L
V
N
P
D
K
E
T
V
F
P
Frog
Xenopus laevis
NP_001088271
859
97399
S131
S
R
A
G
D
Q
C
S
R
L
L
E
L
V
K
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
A135
R
G
N
G
D
R
C
A
R
L
L
E
L
V
R
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
V148
P
Q
Y
P
S
T
A
V
D
F
K
Y
Y
L
K
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
R392
H
C
H
Q
R
P
Q
R
L
S
R
N
E
L
K
Honey Bee
Apis mellifera
XP_394107
1016
115998
V172
S
R
M
Y
T
S
L
V
G
R
R
E
E
L
N
Nematode Worm
Caenorhab. elegans
P91119
710
81117
R66
P
D
L
S
M
K
R
R
V
I
L
E
T
S
D
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
S144
H
K
I
L
M
N
V
S
I
L
T
N
G
D
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
100
100
N.A.
N.A.
0
0
N.A.
0
0
0
0
0
20
13.3
13.3
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
20
13.3
N.A.
6.6
20
13.3
6.6
20
26.6
33.3
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
0
0
8
8
0
0
8
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
22
8
0
0
0
0
0
0
0
% C
% Asp:
8
15
15
0
22
8
0
0
15
0
0
8
22
8
29
% D
% Glu:
0
8
22
8
0
0
0
0
0
0
8
36
22
0
0
% E
% Phe:
8
8
0
0
0
0
0
0
0
8
0
22
0
8
0
% F
% Gly:
0
8
0
22
8
0
8
0
8
0
0
0
8
0
0
% G
% His:
15
0
8
8
0
8
0
0
0
0
0
0
0
22
0
% H
% Ile:
8
0
8
0
8
0
0
0
15
8
0
0
0
0
0
% I
% Lys:
22
29
0
0
0
8
0
0
0
8
8
0
0
0
29
% K
% Leu:
0
0
15
8
8
0
29
8
8
29
36
8
22
29
0
% L
% Met:
0
0
8
0
36
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
0
8
8
0
0
0
0
15
0
0
8
% N
% Pro:
22
0
0
8
0
29
0
8
22
22
0
0
0
0
8
% P
% Gln:
0
8
0
29
0
15
15
0
0
0
0
0
0
0
0
% Q
% Arg:
8
15
0
0
8
8
8
15
22
15
36
0
8
0
15
% R
% Ser:
15
8
0
8
8
8
0
22
8
15
0
0
0
8
8
% S
% Thr:
0
0
0
0
8
8
0
22
0
0
8
8
8
0
0
% T
% Val:
0
0
0
0
0
8
8
15
8
0
0
0
8
22
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
0
0
0
0
0
8
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _